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Increased Platelet Reactivity in HIV-1–Infected Patients Receiving Abacavir-Containing Antiretroviral Therapy
Author(s) -
Claudette Satchell,
Jane A. O’Halloran,
Aoife G. Cotter,
Aaron Peace,
Eileen O’Connor,
Anthony Tedesco,
Eoin R. Feeney,
John S. Lambert,
Gerard Sheehan,
Dermot Kenny,
Patrick Mallon
Publication year - 2011
Publication title -
the journal of infectious diseases
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1093/infdis/jir509
Subject(s) - abacavir , platelet , medicine , epinephrine , p2y12 , pharmacology , immunology , endocrinology , human immunodeficiency virus (hiv) , viral load , platelet aggregation , antiretroviral therapy
Current or recent use of abacavir for treating human immunodeficiency virus type 1 (HIV-1) infection has been associated with increased rates of myocardial infarction (MI). Given the role of platelet aggregation in thrombus formation in MI and the reversible nature of the abacavir association, we hypothesized that patients treated with abacavir would have increased platelet reactivity.

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