Open AccessInternational Spread of an Epidemic Population of Salmonella enterica Serotype Kentucky ST198 Resistant to Ciprofloxacin
Author(s) -
Simon Le Hello,
René S. Hendriksen,
Benoît Doublet,
M. Fisher,
Eva Møller Nielsen,
Jean M. Whichard,
Brahim Bouchrif,
Kayode Fashae,
Sophie A. Granier,
Nathalie Jourdan–Da Silva,
Axel Cloeckaert,
E. J. Threlfall,
Frederick J. Angulo,
Frank M. Aarestrup,
John Wain,
FrançoisXavier Weill
Publication year - 2011
Publication title -
the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1093/infdis/jir409
Subject(s) - salmonella enterica , salmonella , serotype , clone (java method) , ciprofloxacin , biology , multilocus sequence typing , population , microbiology and biotechnology , cluster (spacecraft) , multiple drug resistance , virology , drug resistance , genotype , bacteria , environmental health , medicine , genetics , antibiotics , gene , computer science , programming language
National Salmonella surveillance systems from France, England and Wales, Denmark, and the United States identified the recent emergence of multidrug-resistant isolates of Salmonella enterica serotype Kentucky displaying high-level resistance to ciprofloxacin. A total of 489 human cases were identified during the period from 2002 (3 cases) to 2008 (174 cases). These isolates belonged to a single clone defined by the multilocus sequence type ST198, the XbaI-pulsed-field gel electrophoresis cluster X1, and the presence of the Salmonella genomic island 1 variant SGI1-K. This clone was probably selected in 3 steps in Egypt during the 1990s and the early 2000s and has now spread to several countries in Africa and, more recently, in the Middle East. Poultry has been identified as a potential major vehicle for infection by this clone. Continued surveillance and appropriate control measures should be implemented by national and international authorities to limit the spread of this strain.
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