Estimated Prevalence and Number of Persons With Isolated Antibody to Hepatitis B Core Antigen and Associated Occult Hepatitis B, United States, 2001–2018 | Zendy

Philip R. Spradling | Zendy; Jian Xing | Zendy; Aaron M. Harris | Zendy; Kathleen N. Ly | Zendy

Open Access

Estimated Prevalence and Number of Persons With Isolated Antibody to Hepatitis B Core Antigen and Associated Occult Hepatitis B, United States, 2001–2018

Author(s) -

Philip R. Spradling,

Jian Xing,

Aaron M. Harris,

Kathleen N. Ly

Publication year - 2021

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1093/infdis/jiab366

Subject(s) - medicine , occult , hepatitis b virus , transmission (telecommunications) , hepatitis b , antibody , population , hepatocellular carcinoma , national health and nutrition examination survey , virology , immunology , demography , environmental health , virus , pathology , alternative medicine , electrical engineering , engineering , sociology

Persons with isolated antibody to hepatits B virus (HBV) core antigen (IAHBc) may have occult HBV infection (OBI), which is associated with reactivation and potential risk for hepatocellular carcinoma and HBV transmission. We used National Health and Nutrition Examination Survey data to estimate US IAHBc prevalence and published studies of IAHBc-associated OBI prevalence to estimate OBI burden. During 2001−2018, the prevalence of IAHBc was 0.8% (approximately 2.1 million persons), and the OBI burden range was 35 500–83 600 persons. These data support the need for more robust estimates of IAHBc-associated OBI prevalence in the general US population.

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