Open AccessThirteen-Valent Pneumococcal Conjugate Vaccine–Induced Immunoglobulin G (IgG) Responses in Serum Associated With Serotype-Specific IgG in the Lung
Author(s) -
Elena Mitsi,
Daniella McLenaghan,
AsiaSophia Wolf,
Scott Jones,
Andrea M. Collins,
Angela Hyder-Wright,
David Goldblatt,
Robert S. Heyderman,
Stephen B. Gordon,
Daniela M. Ferreira
Publication year - 2021
Publication title -
the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1093/infdis/jiab331
Subject(s) - bronchoalveolar lavage , serotype , medicine , immunoglobulin g , immunogenicity , immunology , antibody , pneumococcal pneumonia , streptococcus pneumoniae , immunoglobulin m , pneumonia , immunoglobulin a , pneumococcal conjugate vaccine , virology , lung , microbiology and biotechnology , biology , antibiotics
Pneumococcal conjugate vaccine (PCV) efficacy is lower for noninvasive pneumonia than invasive disease. In this study, participants were immunized with 13-valent PCV (PCV13) or hepatitis A vaccine (control). Bronchoalveolar lavage samples were taken between 2 and 6 months and serum at 4 and 7 weeks postvaccination. In the lung, anti-capsular immunoglobulin G (IgG) levels were higher in the PCV13 group compared to controls for all serotypes, except 3 and 6B. Systemically, IgG levels were elevated in the PCV13 group at 4 weeks for all serotypes, except serotype 3. IgG in bronchoalveolar lavage and serum positively correlated for nearly all serotypes. PCV13 shows poor immunogenicity to serotype 3, implying lack of protective efficacy. Clinical Trials Registration. ISRCTN 45340436.
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