Humanized Transgenic Mice Are Resistant to Chronic Wasting Disease Prions From Norwegian Reindeer and Moose | Zendy

Jonathan D. F. Wadsworth | Zendy; Susan Joiner | Zendy; Jacqueline M. Linehan | Zendy; Kezia Jack | Zendy; Huda Al-Doujaily | Zendy; H. Da Costa | Zendy; Thea Ingold | Zendy; Maged M. Taema | Zendy; Fuquan Zhang | Zendy; Malin Sandberg | Zendy; Sebastian Brandner | Zendy; Linh Tran | Zendy; Turid Vikøren | Zendy; Jørn Våge | Zendy; Knut Madslien | Zendy; Bjørnar Ytrehus | Zendy; Sylvie L. Benestad | Zendy; Emmanuel A. Asante | Zendy; John Collinge | Zendy

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Humanized Transgenic Mice Are Resistant to Chronic Wasting Disease Prions From Norwegian Reindeer and Moose

Author(s) -

Jonathan D. F. Wadsworth,

Susan Joiner,

Jacqueline M. Linehan,

Kezia Jack,

Huda Al-Doujaily,

H. Da Costa,

Thea Ingold,

Maged M. Taema,

Fuquan Zhang,

Malin Sandberg,

Sebastian Brandner,

Linh Tran,

Turid Vikøren,

Jørn Våge,

Knut Madslien,

Bjørnar Ytrehus,

Sylvie L. Benestad,

Emmanuel A. Asante,

John Collinge

Publication year - 2021

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1093/infdis/jiab033

Subject(s) - chronic wasting disease , bovine spongiform encephalopathy , transmissible spongiform encephalopathy , norwegian , biology , virology , disease , prion protein , transgene , transmission (telecommunications) , wasting , scrapie , medicine , pathology , gene , genetics , linguistics , philosophy , electrical engineering , engineering , endocrinology

Chronic wasting disease (CWD) is the transmissible spongiform encephalopathy or prion disease affecting cervids. In 2016 the first cases of CWD were reported in Europe in Norwegian wild reindeer and moose. The origin and zoonotic potential of these new prion isolates remain unknown. In this study to investigate zoonotic potential we inoculated brain tissue from CWD-infected Norwegian reindeer and moose into transgenic mice overexpressing human prion protein. After prolonged post-inoculation survival periods no evidence for prion transmission was seen suggesting that the zoonotic potential of these isolates is low.

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