Increased Levels of Interleukin-1 and Soluble Intercellular Adhesion Molecule-1 in Cerebrospinal Fluid of Patients with Subacute Sclerosing Panencephalitis | Zendy

Payal Mehta | Zendy; J Kulczycki | Zendy; Shikhar Mehta | Zendy; Patricia K. Coyle | Zendy; H. M. Wisniewski | Zendy

Open Access

Increased Levels of Interleukin-1 and Soluble Intercellular Adhesion Molecule-1 in Cerebrospinal Fluid of Patients with Subacute Sclerosing Panencephalitis

Author(s) -

Payal Mehta,

J Kulczycki,

Shikhar Mehta,

Patricia K. Coyle,

H. M. Wisniewski

Publication year - 1997

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1093/infdis/175.3.689

Subject(s) - subacute sclerosing panencephalitis , cerebrospinal fluid , proinflammatory cytokine , pathogenesis , medicine , multiple sclerosis , intercellular adhesion molecule 1 , immunology , interleukin , tumor necrosis factor alpha , pathology , cell adhesion molecule , cytokine , inflammation , measles virus , measles , vaccination

Proinflammatory cytokines (interleukin [IL]-1beta, tumor necrosis factor [TNF]-alpha, and IL-6) and soluble intercellular adhesion molecule-1 (sICAM-1) were measured in paired cerebrospinal fluid (CSF) and serum samples from patients with subacute sclerosing panencephalitis (SSPE), multiple sclerosis (MS), or other neurologic diseases (OND) by ELISA. IL-1beta was significantly increased in CSF of the SSPE group compared with levels in the MS or OND group. IL-1beta CSF/serum ratios were higher in the SSPE than in the MS or OND group. TNF-alpha and IL-6 levels were similar in the 3 groups. CSF sICAM-1 was higher in the SSPE group than in the MS or OND group. sICAM-1 CSF/serum ratios were higher in the SSPE than the OND group. The increased CSF/serum ratios of IL-1beta and sICAM-1 in SSPE indicate synthesis of IL-1beta and sICAM-1 in the central nervous system and may be important in the pathogenesis of disease.

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