Molecular Comparison of Group A Streptococci of T1M1 Serotype from Invasive and Noninvasive Infections in Finland | Zendy

Anna Muotiala | Zendy; Helena Seppälä | Zendy; Pentti Huovinen | Zendy; Jaana VuopioVarkila | Zendy

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Molecular Comparison of Group A Streptococci of T1M1 Serotype from Invasive and Noninvasive Infections in Finland

Author(s) -

Anna Muotiala,

Helena Seppälä,

Pentti Huovinen,

Jaana VuopioVarkila

Publication year - 1997

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1093/infdis/175.2.392

Subject(s) - ribotyping , serotype , biology , genotyping , genotype , typing , microbiology and biotechnology , restriction enzyme , genomic dna , restriction fragment length polymorphism , molecular epidemiology , virology , gene , genetics

A total of 98 isolates of group A streptococci of T1M1 serotype isolated in Finland during 1988-1995 from bacteremic, pharyngeal, and pyogenic infections were studied by molecular means. The typing techniques used included restriction endonuclease analysis, ribotyping, and random amplified polymorphic DNA analysis. Representatives of each observed genotype were also examined for carriage of the speA gene encoding for pyrogenic exotoxin A. All of the serotype T1M1 isolates studied were considered to be of a single clonal origin, and 66% were identical by all three genotyping techniques used. Among the remaining 34% of closely related isolates, 13 different genotypes were detected. All isolates studied carried the speA gene. No evidence was found of correlation of the genomic type to the severity of the infection or the time of isolation.

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