Polymorphisms within the Human Tumor Necrosis Factor- Promoter Region in Human Immunodeficiency Virus Type 1-Seropositive Persons | Zendy

Brigitta M. N. Brinkman | Zendy; Ireneus P.M. Keet | Zendy; Frank Miedema | Zendy; C L Verweij | Zendy; Michèl R. Klein | Zendy

Open Access

Polymorphisms within the Human Tumor Necrosis Factor- Promoter Region in Human Immunodeficiency Virus Type 1-Seropositive Persons

Author(s) -

Brigitta M. N. Brinkman,

Ireneus P.M. Keet,

Frank Miedema,

C L Verweij,

Michèl R. Klein

Publication year - 1997

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1093/infdis/175.1.188

Subject(s) - virology , tumor necrosis factor alpha , biology , virus , human immunodeficiency virus (hiv) , immunology , necrosis , medicine , genetics

The question is addressed whether particular tumor necrosis factor-alpha (TNF-alpha) polymorphisms are associated with clinical course and outcome of human immunodeficiency virus type 1 (HIV-1) infection. The distribution of four TNF-alpha guanine (G) to adenosine (A) transition polymorphisms at positions -376, -308, -238, and -163 of the 5' promoter region of the TNF-alpha gene was studied in a nested case-control study among HIV-1-seropositive participants of the Amsterdam Cohort. None of the polymorphisms was significantly associated with long-term asymptomatic survival after HIV-1 infection compared with progression to clinical AIDS. Moreover, specific AIDS-defining illnesses or biologic phenotype of the HIV-1 virus were not associated with TNF-alpha alleles. The results of this study do not point toward a role for known TNF-alpha G to A transition polymorphisms in the clinical course of HIV-1 infection.

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