Maternal Virus Load during Pregnancy and Mother-to-Child Transmission of Human Immunodeficiency Virus Type 1: The French Perinatal Cohort Studies | Zendy

M. J. Mayaux | Zendy; Élisabeth Dussaix | Zendy; J. Isopet | Zendy; Claire Rekacewicz | Zendy; Laurent Mandelbrot | Zendy; N CiraruVigneron | Zendy; M. C. Allemon | Zendy; V. Chambrin | Zendy; Christine Katlama | Zendy; Jean François Delfraissy | Zendy; J Puel | Zendy

Open Access

Maternal Virus Load during Pregnancy and Mother-to-Child Transmission of Human Immunodeficiency Virus Type 1: The French Perinatal Cohort Studies

Author(s) -

M. J. Mayaux,

Élisabeth Dussaix,

J. Isopet,

Claire Rekacewicz,

Laurent Mandelbrot,

N CiraruVigneron,

M. C. Allemon,

V. Chambrin,

Christine Katlama,

Jean François Delfraissy,

J Puel

Publication year - 1997

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1093/infdis/175.1.172

Subject(s) - pregnancy , viral load , transmission (telecommunications) , virus , confidence interval , virology , medicine , cohort , viral disease , sida , cohort study , lentivirus , human immunodeficiency virus (hiv) , gestation , obstetrics , biology , immunology , genetics , electrical engineering , engineering

Virus load in pregnancy and its relation to mother-to-child human immunodeficiency virus (HIV) transmission were studied prospectively. From 1989 to 1994, 320 HIV-infected women from 18 centers had plasma samples stored. Among women not receiving antiretroviral therapy, the polymerase chain reaction RNA level was 3.6 log at delivery, and 15% of women had levels below the detection limit. There was no variation during pregnancy. Women born in sub-Saharan Africa had lower RNA levels, although their CD4 cell distribution did not differ from that in other women. Among 236 evaluable children, 19% +/- 5% were infected. Transmission occurred in 12% of cases (confidence interval, 5%-22%) with <1000 copies/mL versus 29% +/- 10% of those with >10,000 copies/mL (P < .02). Maternal virus load appears strongly related to HIV transmission to the child.

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