Alteration of Interleukin-2 (IL-2) and Soluble IL-2 Receptor Secretion in the Sera and Urine of Patients with Rickettsial Boutonneuse Fever | Zendy

S Mansueto | Zendy; Fortunato D’Ancona | Zendy; P. Colletti | Zendy; Russell F. Graceffa | Zendy; Francesco La Seta | Zendy; V.L. Pecoraro | Zendy; G Gambino | Zendy; Graciela Grillo | Zendy; G. Vitale | Zendy; Pierina Richiusa | Zendy; P. D’Agostino | Zendy; Enrìco Cillari | Zendy

Open Access

Alteration of Interleukin-2 (IL-2) and Soluble IL-2 Receptor Secretion in the Sera and Urine of Patients with Rickettsial Boutonneuse Fever

Author(s) -

S Mansueto,

Fortunato D’Ancona,

P. Colletti,

Russell F. Graceffa,

Francesco La Seta,

V.L. Pecoraro,

G Gambino,

Graciela Grillo,

G. Vitale,

Pierina Richiusa,

P. D’Agostino,

Enrìco Cillari

Publication year - 1997

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1093/infdis/175.1.142

Subject(s) - boutonneuse fever , urine , peripheral blood mononuclear cell , immunology , interleukin 2 , rickettsiosis , interleukin , medicine , receptor , cytokine , biology , serology , antibody , biochemistry , in vitro

Sera and urine samples from 115 Sicilian patients with boutonneuse fever (BF), obtained at the time of diagnosis and after clinical recovery, were analyzed for concentrations of interleukin (IL)-2 and soluble IL-2 receptor (sIL-2R). There were significantly high levels of sIL-2R in the urine and sera of patients with acute BF compared with healthy controls, and the values returned to normal following successful chemotherapy. The data indicate that the sIL-2R urine concentrations correlated directly with the sIL-2R sera levels. In contrast, in all tested sera and urine samples, IL-2 levels were normal. Furthermore, a reduction in IL-2 production by peripheral blood mononuclear cells from acute BF patients was also observed. sIL-2R represents an unspecific marker useful to monitor the evolution of BF.

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