Mathematically modelling the effects of counting factor in Dictyostelium discoideum | Zendy

J. C. Dallon | Zendy; Wonhee Jang | Zendy; Richard H. Gomer | Zendy

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Mathematically modelling the effects of counting factor in Dictyostelium discoideum

Author(s) -

J. C. Dallon,

Wonhee Jang,

Richard H. Gomer

Publication year - 2005

Publication title -

mathematical medicine and biology a journal of the ima

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.542

H-Index - 45

eISSN - 1477-8602

pISSN - 1477-8599

DOI - 10.1093/imammb/dqi016

Subject(s) - dictyostelium discoideum , breakup , cellular automaton , biological system , biology , mechanism (biology) , motility , computer science , computational biology , microbiology and biotechnology , physics , mechanics , artificial intelligence , genetics , gene , quantum mechanics

Size regulation is a crucial feature in many biological systems, with misregulation leading to dysplasia or hyperplasia. The recent discovery of counting factor (CF) in Dictyostelium discoideum will lead to a greater understanding of how the system regulates the size of a group of cells. In this paper we mathematically model the known effects of CF using two different models: a cellular automata model and a discrete continuum hybrid model. With the use of these models we are able to understand how modulation of adhesion and motile forces by CF can facilitate stream breakup. In addition, the modelling suggests a new possible mechanism for stream breakup involving the frequency of cell reorientation.

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