Animal Models of Focal and Global Cerebral Ischemia | Zendy

Richard J. Traystman | Zendy

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Animal Models of Focal and Global Cerebral Ischemia

Author(s) -

Richard J. Traystman

Publication year - 2003

Publication title -

ilar journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.129

H-Index - 75

eISSN - 1930-6180

pISSN - 1084-2020

DOI - 10.1093/ilar.44.2.85

Subject(s) - neuroprotection , ischemia , stroke (engine) , medicine , intensive care medicine , global population , human studies , animal model , population , neuroscience , bioinformatics , cardiology , pharmacology , psychology , biology , environmental health , mechanical engineering , engineering

The use of appropriate animal models is essential to predict the value and effect of therapeutic approaches in human subjects. Focal (stroke) and global (cardiac arrest) cerebral ischemia represents diseases that are common in the human population. Stroke and cardiac arrest, which are major causes of death and disability, affect millions of individuals around the world and are responsible for the leading health care costs of all diseases. Understanding the mechanisms of injury and neuroprotection in these diseases is critical if we are ever to learn new target sites to treat ischemia. There are many animal models available to investigate injury mechanisms and neuroprotective strategies. This review summarizes many (but not all) small and large animal models of focal and global cerebral ischemia and discusses their advantages and disadvantages.

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