WKY Fatty Rat as a Model of Obesity and Non-insulin-dependent Diabetes Mellitus

Health. Peterson, R. G., A. K. Sharma, L. A. Little, M. Neel, C. G. Potter, and J. Eichberg. 1988b. Peripheral nerve abnormalities in Wistar fatty diabetic rats. Pp. 488-491 in Frontiers in Diabetes Research. Lessons from Animal Diabetes II, E. Shafrir and A. E. Renold, eds. London: John Libbey. Seino, Y., S. Seino, M. Usami, K. Tsuda, J. Takemura, S. Nishi, H. Ishida, and H. Imura. 1984. Somatostatin, glucagon, and insulin secretion from isolated perfused pancreas of new genetically obese hyperglycemic rats. Metabolism 33(5):429-431. Sugiyama, Y., Y. Shimura, and H. Ikeda. 1989a. Pathogenesis of hyperglycemia in genetically obese-hyperglycemic rats, Wistar fatty: Presence of hepatic insulin resistance. Endocrinol. Japon. 36(1):6573. Sugiyama, Y., Y. Shimura, and H. Ikeda. 1989b. Derangement in hepatic enzymes caused by sucrose-drinking and its implication for the development of hyperglycemia in female Wistar fatty rats. Endocrinol. Japon. 36(2):245-251. Sussman, K. 1985. Spectrum of defects in non-insulin-dependent diabetes mellitus. Am. J. Med. 79 (suppl. 79): 1-5. Terrettaz, J., and B. Jeanrenaud. 1983. In vivo hepatic and peripheral insulin resistance in genetically obese (fa/fa) rats. Endocrinology 112:1346-1351. West, D. B., R. Rohlfing, R. Kava, and M. R. C. Greenwood. In press. Hepatic glucose production (HGP) is elevated in obese diabetic Wistar fatty (Wf) rats. Int. J. Obesity (abstr.). Zucker, L. M., and T. F. Zucker. 1961. Fatty, a new mutation in the rat. J. Hered. 52:275-278.