Open AccessPostsynaptic Mechanisms Render Syn I/II/III Mice Highly Responsive to Psychostimulants
Author(s) -
Vladimir M. Pogorelov,
HungTeh Kao,
George J Augustine,
William C. Wetsel
Publication year - 2019
Publication title -
the international journal of neuropsychopharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.897
H-Index - 107
eISSN - 1469-5111
pISSN - 1461-1457
DOI - 10.1093/ijnp/pyz019
Subject(s) - dopamine , postsynaptic potential , chemistry , knockout mouse , neurotransmitter , agonist , open field , sensitization , pharmacology , neuroscience , microdialysis , endocrinology , biology , receptor , biochemistry
These results reveal presynaptic dopamine release is not indicative of agonist-induced triple knockout hyperlocomotion. Instead, their novelty response occurs primarily through postsynaptic mechanisms and network effects.
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