Essential Role of Histone Methyltransferase G9a in Rapid Tolerance to the Anxiolytic Effects of Ethanol | Zendy

Tiffani D.M. Berkel | Zendy; Huaibo Zhang | Zendy; Tara Teppen | Zendy; Amul J. Sakharkar | Zendy; Subhash C. Pandey | Zendy

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Essential Role of Histone Methyltransferase G9a in Rapid Tolerance to the Anxiolytic Effects of Ethanol

Author(s) -

Tiffani D.M. Berkel,

Huaibo Zhang,

Tara Teppen,

Amul J. Sakharkar,

Subhash C. Pandey

Publication year - 2018

Publication title -

the international journal of neuropsychopharmacology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.897

H-Index - 107

eISSN - 1469-5111

pISSN - 1461-1457

DOI - 10.1093/ijnp/pyy102

Subject(s) - anxiolytic , histone deacetylase , ethanol , elevated plus maze , neuropeptide y receptor , neuropeptide , chemistry , endocrinology , pharmacology , amygdala , medicine , liquid diet , histone deacetylase inhibitor , biochemistry , histone , anxiety , psychiatry , receptor , gene

Tolerance to ethanol-induced anxiolysis promotes alcohol intake, thus contributing to alcohol use disorder development. Recent studies implicate histone deacetylase-mediated histone H3K9 deacetylation in regulating neuropeptide Y expression during rapid ethanol tolerance to the anxiolytic effects of ethanol. Furthermore, the histone methyltransferase, G9a, and G9a-mediated H3K9 dimethylation (H3K9me2) have recently emerged as regulators of addiction and anxiety; however, their role in rapid ethanol tolerance is unknown. Therefore, we investigated the role of G9a-mediated H3K9me2 in neuropeptide Y expression during rapid ethanol tolerance.

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