Glutamatergic Signaling Drives Ketamine-Mediated Response in Depression: Evidence from Dynamic Causal Modeling | Zendy

Jessica R. Gilbert | Zendy; Julia S. Yarrington | Zendy; Kathleen E. Wills | Zendy; Allison C. Nugent | Zendy; Carlos A. Zarate | Zendy

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Glutamatergic Signaling Drives Ketamine-Mediated Response in Depression: Evidence from Dynamic Causal Modeling

Author(s) -

Jessica R. Gilbert,

Julia S. Yarrington,

Kathleen E. Wills,

Allison C. Nugent,

Carlos A. Zarate

Publication year - 2018

Publication title -

the international journal of neuropsychopharmacology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.897

H-Index - 107

eISSN - 1469-5111

pISSN - 1461-1457

DOI - 10.1093/ijnp/pyy041

Subject(s) - glutamatergic , depression (economics) , neuroscience , psychology , ketamine , response inhibition , glutamate receptor , medicine , cognition , receptor , economics , macroeconomics

The glutamatergic modulator ketamine has rapid antidepressant effects in individuals with major depressive disorder and bipolar depression. Thus, modulating glutamatergic transmission may be critical to effectively treating depression, though the mechanisms by which this occurs are not fully understood.

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