Association of BDNF Val66Met Polymorphism and Brain BDNF Levels with Major Depression and Suicide | Zendy

Mariam M. Youssef | Zendy; Mark D. Underwood | Zendy; Yungyu Huang | Zendy; Shuchi Hsiung | Zendy; Yan Liu | Zendy; Norman R. Simpson | Zendy; Mihran J. Bakalian | Zendy; Gorazd Rosoklija | Zendy; Andrew J. Dwork | Zendy; Victoria Arango | Zendy; J. John Mann | Zendy

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Association of BDNF Val66Met Polymorphism and Brain BDNF Levels with Major Depression and Suicide

Author(s) -

Mariam M. Youssef,

Mark D. Underwood,

Yungyu Huang,

Shuchi Hsiung,

Yan Liu,

Norman R. Simpson,

Mihran J. Bakalian,

Gorazd Rosoklija,

Andrew J. Dwork,

Victoria Arango,

J. John Mann

Publication year - 2018

Publication title -

the international journal of neuropsychopharmacology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.897

H-Index - 107

eISSN - 1469-5111

pISSN - 1461-1457

DOI - 10.1093/ijnp/pyy008

Subject(s) - neurotrophic factors , psychology , brain derived neurotrophic factor , major depressive disorder , anterior cingulate cortex , medicine , neuroscience , dorsolateral prefrontal cortex , neurotrophin , psychiatry , prefrontal cortex , endocrinology , amygdala , cognition , receptor

Brain-derived neurotrophic factor is implicated in the pathophysiology of major depressive disorder and suicide. Both are partly caused by early life adversity, which reduces brain-derived neurotrophic factor protein levels. This study examines the association of brain-derived neurotrophic factor Val66Met polymorphism and brain brain-derived neurotrophic factor levels with depression and suicide. We hypothesized that both major depressive disorder and early life adversity would be associated with the Met allele and lower brain brain-derived neurotrophic factor levels. Such an association would be consistent with low brain-derived neurotrophic factor mediating the effect of early life adversity on adulthood suicide and major depressive disorder.

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