Involvement of Epigenetic Modifications of GABAergic Interneurons in Basolateral Amygdala in Anxiety-like Phenotype of Prenatally Stressed Mice | Zendy

Chunting Zhu | Zendy; Min Liang | Zendy; Yingchun Li | Zendy; Xuejiao Feng | Zendy; Juan Hong | Zendy; Rong Zhou | Zendy

Open Access

Involvement of Epigenetic Modifications of GABAergic Interneurons in Basolateral Amygdala in Anxiety-like Phenotype of Prenatally Stressed Mice

Author(s) -

Chunting Zhu,

Min Liang,

Yingchun Li,

Xuejiao Feng,

Juan Hong,

Rong Zhou

Publication year - 2018

Publication title -

the international journal of neuropsychopharmacology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.897

H-Index - 107

eISSN - 1469-5111

pISSN - 1461-1457

DOI - 10.1093/ijnp/pyy006

Subject(s) - glutamate decarboxylase , basolateral amygdala , gabaergic , prenatal stress , amygdala , epigenetics , neuroscience , biology , endocrinology , medicine , genetics , inhibitory postsynaptic potential , biochemistry , gene , pregnancy , gestation , enzyme

Prenatal stress is considered a risk factor for anxiety disorder. Downregulation in the expression of GABAergic gene, that is, glutamic acid decarboxylase 67, associated with DNA methyltransferase overexpression in GABAergic neurons has been regarded as a characteristic component of anxiety disorder. Prenatal stress has an adverse effect on the development of the basolateral amygdala, which is a key region in anxiety regulation. The aim of this study is to analyze the possibility of epigenetic alterations of GABAergic neurons in the basolateral amygdala participating in prenatal stress-induced anxiety.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research