Interferon-Alpha Reduces Human Hippocampal Neurogenesis and Increases Apoptosis via Activation of Distinct STAT1-Dependent Mechanisms | Zendy

Alessandra Borsini | Zendy; Annamaria Cattaneo | Zendy; Chiara Malpighi | Zendy; Sandrine Thuret | Zendy; Neil A. Harrison | Zendy; Patricia A. Zunszain | Zendy; Carmine M. Pariante | Zendy

Open Access

Interferon-Alpha Reduces Human Hippocampal Neurogenesis and Increases Apoptosis via Activation of Distinct STAT1-Dependent Mechanisms

Author(s) -

Alessandra Borsini,

Annamaria Cattaneo,

Chiara Malpighi,

Sandrine Thuret,

Neil A. Harrison,

Patricia A. Zunszain,

Carmine M. Pariante

Publication year - 2017

Publication title -

the international journal of neuropsychopharmacology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.897

H-Index - 107

eISSN - 1469-5111

pISSN - 1461-1457

DOI - 10.1093/ijnp/pyx083

Subject(s) - neurogenesis , hippocampal formation , apoptosis , neuroscience , alpha (finance) , microbiology and biotechnology , biology , psychology , genetics , developmental psychology , construct validity , psychometrics

In humans, interferon-α treatment for chronic viral hepatitis is a well-recognized clinical model for inflammation-induced depression, but the molecular mechanisms underlying these effects are not clear. Following peripheral administration in rodents, interferon-α induces signal transducer and activator of transcription-1 (STAT1) within the hippocampus and disrupts hippocampal neurogenesis.

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