Occupancy of Norepinephrine Transporter by Duloxetine in Human Brains Measured by Positron Emission Tomography with (S,S)-[18F]FMeNER-D2 | Zendy

Sho Moriguchi | Zendy; Harumasa Takano | Zendy; Yasuyuki Kimura | Zendy; Tomohisa Nagashima | Zendy; Keisuke Takahata | Zendy; Manabu Kubota | Zendy; Soichiro Kitamura | Zendy; Tatsuya Ishii | Zendy; Masanori Ichise | Zendy; Ming-Rong Zhang | Zendy; Hitoshi Shimada | Zendy; Masaru Mimura | Zendy; Jeffrey H. Meyer | Zendy; Makoto Higuchi | Zendy; Tetsuya Suhara | Zendy

Open Access

Occupancy of Norepinephrine Transporter by Duloxetine in Human Brains Measured by Positron Emission Tomography with (S,S)-[18F]FMeNER-D2

Author(s) -

Sho Moriguchi,

Harumasa Takano,

Yasuyuki Kimura,

Tomohisa Nagashima,

Keisuke Takahata,

Manabu Kubota,

Soichiro Kitamura,

Tatsuya Ishii,

Masanori Ichise,

Ming-Rong Zhang,

Hitoshi Shimada,

Masaru Mimura,

Jeffrey H. Meyer,

Makoto Higuchi,

Tetsuya Suhara

Publication year - 2017

Publication title -

the international journal of neuropsychopharmacology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.897

H-Index - 107

eISSN - 1469-5111

pISSN - 1461-1457

DOI - 10.1093/ijnp/pyx069

Subject(s) - norepinephrine transporter , duloxetine , norepinephrine , serotonin transporter , positron emission tomography , reuptake inhibitor , medicine , serotonin plasma membrane transport proteins , endocrinology , pharmacology , chemistry , serotonin , nuclear medicine , dopamine , pathology , receptor , alternative medicine

The norepinephrine transporter in the brain has been targeted in the treatment of psychiatric disorders. Duloxetine is a serotonin and norepinephrine reuptake inhibitor that has been widely used for the treatment of depression. However, the relationship between dose and plasma concentration of duloxetine and norepinephrine transporter occupancy in the human brain has not been determined. In this study, we examined norepinephrine transporter occupancy by different doses of duloxetine.

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