Adolescent Alcohol Exposure-Induced Changes in Alpha-Melanocyte Stimulating Hormone and Neuropeptide Y Pathways via Histone Acetylation in the Brain During Adulthood | Zendy

Dadasaheb M. Kokare | Zendy; Evan J. Kyzar | Zendy; Huaibo Zhang | Zendy; Amul J. Sakharkar | Zendy; Subhash C. Pandey | Zendy

Open Access

Adolescent Alcohol Exposure-Induced Changes in Alpha-Melanocyte Stimulating Hormone and Neuropeptide Y Pathways via Histone Acetylation in the Brain During Adulthood

Author(s) -

Dadasaheb M. Kokare,

Evan J. Kyzar,

Huaibo Zhang,

Amul J. Sakharkar,

Subhash C. Pandey

Publication year - 2017

Publication title -

the international journal of neuropsychopharmacology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.897

H-Index - 107

eISSN - 1469-5111

pISSN - 1461-1457

DOI - 10.1093/ijnp/pyx041

Subject(s) - melanocortin , neuropeptide y receptor , neuropeptide , endocrinology , melanocyte stimulating hormone , medicine , epigenetics , acetylation , receptor , histone , hormone , biology , chemistry , biochemistry , gene

Adolescent intermittent ethanol exposure causes long-lasting alterations in brain epigenetic mechanisms. Melanocortin and neuropeptide Y signaling interact and are affected by ethanol exposure in the brain. Here, the persistent effects of adolescent intermittent ethanol on alpha-melanocyte stimulating hormone, melanocortin 4 receptor, and neuropeptide Y expression and their regulation by histone acetylation mechanisms were investigated in adulthood.

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