Loss of Parvalbumin in the Hippocampus of MAM Schizophrenia Model Rats Is Attenuated by Peripubertal Diazepam | Zendy

Yijuan Du | Zendy; Anthony A. Grace | Zendy

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Loss of Parvalbumin in the Hippocampus of MAM Schizophrenia Model Rats Is Attenuated by Peripubertal Diazepam

Author(s) -

Yijuan Du,

Anthony A. Grace

Publication year - 2016

Publication title -

the international journal of neuropsychopharmacology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.897

H-Index - 107

eISSN - 1469-5111

pISSN - 1461-1457

DOI - 10.1093/ijnp/pyw065

Subject(s) - parvalbumin , basolateral amygdala , dentate gyrus , subiculum , hippocampus , diazepam , hippocampal formation , neuroscience , endocrinology , amygdala , medicine , interneuron , psychology , biology , psychiatry , inhibitory postsynaptic potential

Loss of parvalbumin interneurons in the hippocampus is a robust finding in schizophrenia brains. Rats exposed during embryonic day 17 to methylazoxymethanol acetate exhibit characteristics consistent with an animal model of schizophrenia, including decreased parvalbumin interneurons in the ventral hippocampus. We reported previously that peripubertal administration of diazepam prevented the emergence of pathophysiology in adult methylazoxymethanol acetate rats.

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