The Subjective Response to Nitrous Oxide is a Potential Pharmaco-Endophenotype for Alcohol Use Disorder: A Preliminary Study with Heavy Drinkers | Zendy

Katie Walsh | Zendy; Ravi Das | Zendy; Sunjeev K. Kamboj | Zendy

Open Access

The Subjective Response to Nitrous Oxide is a Potential Pharmaco-Endophenotype for Alcohol Use Disorder: A Preliminary Study with Heavy Drinkers

Author(s) -

Katie Walsh,

Ravi Das,

Sunjeev K. Kamboj

Publication year - 2016

Publication title -

the international journal of neuropsychopharmacology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.897

H-Index - 107

eISSN - 1469-5111

pISSN - 1461-1457

DOI - 10.1093/ijnp/pyw063

Subject(s) - endophenotype , ketamine , psychology , alcohol use disorder , sedative , stimulant , alcohol , medicine , psychiatry , cognition , chemistry , biochemistry

Healthy people with a family history of alcohol problems show a pattern of subjective responses to alcohol that resemble those of affected probands. Studies on ketamine suggest that up-regulation of N-methyl-D-aspartate receptors (NMDARs) underlies these effects, and point to a pharmacologically-responsive endophenotype reflecting enhanced risk for alcohol-use disorders.

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