Down-Regulation of Hippocampal Genes Regulating Dopaminergic, GABAergic, and Glutamatergic Function Following Combined Neonatal Phencyclidine and Post-Weaning Social Isolation of Rats as a Neurodevelopmental Model for Schizophrenia | Zendy

Philip Gaskin | Zendy; Maria ToledoRodriguez | Zendy; S P H Alexander | Zendy; K.C.F. Fone | Zendy

Open Access

Down-Regulation of Hippocampal Genes Regulating Dopaminergic, GABAergic, and Glutamatergic Function Following Combined Neonatal Phencyclidine and Post-Weaning Social Isolation of Rats as a Neurodevelopmental Model for Schizophrenia

Author(s) -

Philip Gaskin,

Maria ToledoRodriguez,

S P H Alexander,

K.C.F. Fone

Publication year - 2016

Publication title -

the international journal of neuropsychopharmacology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.897

H-Index - 107

eISSN - 1469-5111

pISSN - 1461-1457

DOI - 10.1093/ijnp/pyw062

Subject(s) - phencyclidine , prepulse inhibition , dopaminergic , gabaergic , dopamine , glutamatergic , hippocampal formation , neuroscience , schizophrenia (object oriented programming) , nmda receptor , psychology , glutamate receptor , endocrinology , medicine , pharmacology , biology , psychiatry , receptor , inhibitory postsynaptic potential

Dysfunction of dopaminergic, GABAergic, and glutamatergic function underlies many core symptoms of schizophrenia. Combined neonatal injection of the N-methyl-D-aspartate (NMDA) receptor antagonist, phencyclidine (PCP), and post-weaning social isolation of rats produces a behavioral syndrome with translational relevance to several core symptoms of schizophrenia. This study uses DNA microarray to characterize alterations in hippocampal neurotransmitter-related gene expression and examines the ability of the sodium channel blocker, lamotrigine, to reverse behavioral changes in this model.

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