Parvalbumin Interneurons of Central Amygdala Regulate the Negative Affective States and the Expression of Corticotrophin-Releasing Hormone During Morphine Withdrawal | Zendy

Li Wang | Zendy; Minjie Shen | Zendy; Changyou Jiang | Zendy; Lan Ma | Zendy; Feifei Wang | Zendy

Open Access

Parvalbumin Interneurons of Central Amygdala Regulate the Negative Affective States and the Expression of Corticotrophin-Releasing Hormone During Morphine Withdrawal

Author(s) -

Li Wang,

Minjie Shen,

Changyou Jiang,

Lan Ma,

Feifei Wang

Publication year - 2016

Publication title -

the international journal of neuropsychopharmacology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.897

H-Index - 107

eISSN - 1469-5111

pISSN - 1461-1457

DOI - 10.1093/ijnp/pyw060

Subject(s) - optogenetics , amygdala , conditioned place preference , nucleus accumbens , psychology , morphine , neuroscience , central nucleus of the amygdala , parvalbumin , aversive stimulus , gabaergic , basolateral amygdala , medicine , endocrinology , dopamine , inhibitory postsynaptic potential

The central nucleus of the amygdala (CeA) is a crucial component of the neuronal circuitry mediating aversive emotion. Its role in the negative affective states during drug withdrawal includes changes in opioidergic, GABAergic, and corticotropin-releasing factor neurotransmission. However, the modulation of the neurobiological interconnectivity in the CeA and its effects in the negative reinforcement of drug dependents are poorly understood.

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