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s | 101 women with bipolar disorder based on observations that testosterone may affect mood and suicidality. We examined whether testosterone is related to the course of illness at baseline and whether blood testosterone levels predict suicide attempts on follow-up. Methods: Females with a DSM-IV diagnosis of a bipolar disorder in a depressive or mixed episode with at least one past suicide attempt were enrolled. We limited this study to previous suicide attempters in order to have a higher risk group for suicide attempt on follow-up and thus sufficient power to allow detection of a relationship to testosterone and clinical variables. Demographic and clinical parameters were assessed and recorded. Plasma testosterone was assayed using a double antibody radioimmunoassay procedure. Patients were followed up prospectively for up to 2.5 years. The SPSS 19 statistical program was used to perform statistical analyses. Results: At baseline, testosterone levels positively correlated with the number of past major depressive episodes (r=0.353, p=0.014) and suicide attempts (r=0.408, p=0.003) but negatively with the Reasons for Living Scale scores (r=-0.373, p=0.014). We did not find a correlation between testosterone levels and Brown Goodwin lifetime aggression scale scores (r=0.126, p=0.395), the number of manic episodes (r=0.077, p=0.605), current severity of suicide ideation (r=0.133, p=0.425), depression (r=0.027, p=0.850) or hopelessness (r<0.001, p=0.997). The Cox proportional hazards regression analysis demonstrated that higher baseline testosterone levels predicted suicide attempts during the follow up period: HR=169, Wald=6.575, df=1, p=0.01, which means an increase in the testosterone level by 0.1 ng/ml (10 ng/ dl) increases the probability of suicide attempt 16.9 times. Discussion: This prospective study shows that testosterone levels may predict suicide attempts in women with bipolar illness. The results of this study also suggest that testosterone levels may be related to the course of bipolar disorder. Our results are consistent with observations suggesting that testosterone influences mood and behavior in females. For example, an association between blood or saliva testosterone levels and depressive symptoms in women was observed by several research groups. Possibly, depression mediates the relation between testosterone and suicidality. PS279 Completed suicides in 20 years in Lima Vasquez F. Nicolas Y, Falconì S, Chang L, Galindo J, National Institute of Mental Health, Peru Abstract Objective: Study socio demographic profile of complete suicides in patients seen in an Mental Health Institution along last 20 years in Lima. Method: Use of Psychological Autopsy Protocol, review of Clinical History, relatives and friends`s testimonies, newspaper notes and Internet and social net information. Summary Of Results: They were reported 38 patients with completed suicide: 19 male (50 %), 19 female (50 %), age rank from 18 to 82 y.o. Most prevalent age was 18 to 33 y.o: 52.6 %. Almost 40 % were single, and separated 31.5 %; 44.7 % % with secondary school level, being student 31.5 %. The principal diagnosis was Major Depression:57.9 %, the first motivation was sentimental or conjugal conflict: 34.2 %, the two major lethal methods were hanging:52.6 % and jumping:18.4 %.  Suicide patients were in treatment at least 1 to 5 years:44.7 %, and recorded more than 3 previous suicide attempt:52.6 %. At least 52.6 % was hospitalized once. A final letter or note was found in 44.7 %, and 55.3 % of them verbalized suicide intention to their Physician. Conclusions. A profile of patients who completed suicide, seen in this trial, was: gender alike (in General Population (GP) the proportion is 2Male/1 female), mostly young, single or separated with sentimental trouble, Major Depression as first diagnosis in almost 60 % of cases like seen in GP. The principal method was hanging. The second was jumping which is fourth in GP. Also, more than a half of patients made at least 3 suicide attempts, and almost a half received treatment and hospitalized. Finally, almost all communicated their intention either by writing or talking also to their own Psychiatrist.Objective: Study socio demographic profile of complete suicides in patients seen in an Mental Health Institution along last 20 years in Lima. Method: Use of Psychological Autopsy Protocol, review of Clinical History, relatives and friends`s testimonies, newspaper notes and Internet and social net information. Summary Of Results: They were reported 38 patients with completed suicide: 19 male (50 %), 19 female (50 %), age rank from 18 to 82 y.o. Most prevalent age was 18 to 33 y.o: 52.6 %. Almost 40 % were single, and separated 31.5 %; 44.7 % % with secondary school level, being student 31.5 %. The principal diagnosis was Major Depression:57.9 %, the first motivation was sentimental or conjugal conflict: 34.2 %, the two major lethal methods were hanging:52.6 % and jumping:18.4 %.  Suicide patients were in treatment at least 1 to 5 years:44.7 %, and recorded more than 3 previous suicide attempt:52.6 %. At least 52.6 % was hospitalized once. A final letter or note was found in 44.7 %, and 55.3 % of them verbalized suicide intention to their Physician. Conclusions. A profile of patients who completed suicide, seen in this trial, was: gender alike (in General Population (GP) the proportion is 2Male/1 female), mostly young, single or separated with sentimental trouble, Major Depression as first diagnosis in almost 60 % of cases like seen in GP. The principal method was hanging. The second was jumping which is fourth in GP. Also, more than a half of patients made at least 3 suicide attempts, and almost a half received treatment and hospitalized. Finally, almost all communicated their intention either by writing or talking also to their own Psychiatrist. PS280 Dual pathology and suicide attempt in Emergency Room, 2010–2012 Vasquez F., Nicolas Y., Falconì S., Albinagorta P National Institute of Mental Health, Peru Abstract Objective: To study incidence of dual pathology in patients with suicide attempt seeing at Emergency Room (ER) in a Peruvian Mental Health Institute during a tri-annual period. Methods: A descriptive and longitudinal trial, assessing patients at ER with suicide attempts by means of clinical evaluation according DSM IV-RT criteria for establish clinical diagnosis, as well as an instruments for suicide attempt. Results: From a total of 670 patients who presented suicide attempt, 100 of them (14,9 %) were diagnosed with dual pathology: female 79 (79 %), male:21 (21 %).Age rank was 18 to 78 years old. The principal conditions of duality were as follows: Depressive disorders and alcoholism: 61 (61 %), Depression and benzodiazepines: 17 (17 %), Depression and psychoactive substances: 6 (6 %), Bipolar disorder and alcoholism: 10 (10 %); Schizophrenia and alcoholism:3 (3 %),and Anxiety disorders and alcoholism: 3 (3 %). Conclusion: In this trial, it was found almost 15 % of Dual Pathology in patients with suicide attempt, being Alcoholism the major component in Depression, Bipolar, Schizophrenia and Anxiety Disorders,it is 77 % of sample, mostly in depressive states, also as a relevant condition related to suicide attempt. It is important to take a look to Benzodiazepines as a second condition for suicidal behavior. Bibliography: Rosenthal RN, (2012) Implications of epidemiological data for identifying persons with substance abuse and other mental disorders.The American Journal of Addiction, pp 21: 97–103. Casas M.,(2010) Trastornos duales (Trastornos afectivos: ansiedad y depresiòn) 2da Ed. pp 890–899 Masson BarcelonaObjective: To study incidence of dual pathology in patients with suicide attempt seeing at Emergency Room (ER) in a Peruvian Mental Health Institute during a tri-annual period. Methods: A descriptive and longitudinal trial, assessing patients at ER with suicide attempts by means of clinical evaluation according DSM IV-RT criteria for establish clinical diagnosis, as well as an instruments for suicide attempt. Results: From a total of 670 patients who presented suicide attempt, 100 of them (14,9 %) were diagnosed with dual pathology: female 79 (79 %), male:21 (21 %).Age rank was 18 to 78 years old. The principal conditions of duality were as follows: Depressive disorders and alcoholism: 61 (61 %), Depression and benzodiazepines: 17 (17 %), Depression and psychoactive substances: 6 (6 %), Bipolar disorder and alcoholism: 10 (10 %); Schizophrenia and alcoholism:3 (3 %),and Anxiety disorders and alcoholism: 3 (3 %). Conclusion: In this trial, it was found almost 15 % of Dual Pathology in patients with suicide attempt, being Alcoholism the major component in Depression, Bipolar, Schizophrenia and Anxiety Disorders,it is 77 % of sample, mostly in depressive states, also as a relevant condition related to suicide attempt. It is important to take a look to Benzodiazepines as a second condition for suicidal behavior. Bibliography: Rosenthal RN, (2012) Implications of epidemiological data for identifying persons with substance abuse and other mental disorders.The American Journal of Addiction, pp 21: 97–103. Casas M.,(2010) Trastornos duales (Trastornos afectivos: ansiedad y depresiòn) 2da Ed. pp 890–899 Masson Barcelona PS281 Lifetime suicidal ideation and attempt in community adults with full major depressive disorder versus only sustained depressed mood Lifetime suicidal ideation and attempt in community adults with full major depressive disorder versus only sustained depressed mood Running title: Suicide in MDD and depressed mood Hye Jin Yoo, M.D.,1 Jin Pyo Hong, M.D., Ph.D.,1 Maeng Je Cho, M.D., Ph.D.,2 Maurizio Fava, M.D.,3 David Mischoulon, M.D., Ph.D,3 JungYoon Heo, M.D.,1 Kiwon Kim, M.D.,1 Hong Jin Jeon, M.D., Ph.D.1,3,4,* How to cite this article: Yoo HJ, Hong JP, Cho MJ, Fava M, Mischoulon D, Heo JY, Kim KW, Jeon HJ 102 | International Journal of Neuropsychopharmacology

PS281. Lifetime suicidal ideation and attempt in community adults with full major depressive disorder versus only sustained depressed mood