Association of Superoxide Dismutase 2 (SOD2) Genotype with Gray Matter Volume Shrinkage in Chronic Alcohol Users: Replication and Further Evaluation of an Addiction Gene Panel | Zendy

Miri Gitik | Zendy; Vibhuti Srivastava | Zendy; Colin A. Hodgkinson | Zendy; PeiHong Shen | Zendy; David Goldman | Zendy; Dieter J. Meyerhoff | Zendy

Open Access

Association of Superoxide Dismutase 2 (SOD2) Genotype with Gray Matter Volume Shrinkage in Chronic Alcohol Users: Replication and Further Evaluation of an Addiction Gene Panel

Author(s) -

Miri Gitik,

Vibhuti Srivastava,

Colin A. Hodgkinson,

PeiHong Shen,

David Goldman,

Dieter J. Meyerhoff

Publication year - 2016

Publication title -

the international journal of neuropsychopharmacology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.897

H-Index - 107

eISSN - 1469-5111

pISSN - 1461-1457

DOI - 10.1093/ijnp/pyw033

Subject(s) - sod2 , single nucleotide polymorphism , genotype , genetics , psychology , biology , superoxide dismutase , medicine , gene , oxidative stress

Reduction in brain volume, especially gray matter volume, has been shown to be one of the many deleterious effects of prolonged alcohol consumption. High variance in the degree of gray matter tissue shrinkage among alcohol-dependent individuals and a previous neuroimaging genetics report suggest the involvement of environmental and/or genetic factors, such as superoxide dismutase 2 (SOD2). Identification of such underlying factors will help in the clinical management of alcohol dependence.

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