Combined Neuropeptide S and D-Cycloserine Augmentation Prevents the Return of Fear in Extinction-Impaired Rodents: Advantage of Dual versus Single Drug Approaches | Zendy

Simone B. Sartori | Zendy; Verena Maurer | Zendy; Conor P. Murphy | Zendy; Claudia Schmuckermair | Zendy; Patrick Muigg | Zendy; Inga D. Neumann | Zendy; Nigel Whittle | Zendy; Nicolas Singewald | Zendy

Open Access

Combined Neuropeptide S and D-Cycloserine Augmentation Prevents the Return of Fear in Extinction-Impaired Rodents: Advantage of Dual versus Single Drug Approaches

Author(s) -

Simone B. Sartori,

Verena Maurer,

Conor P. Murphy,

Claudia Schmuckermair,

Patrick Muigg,

Inga D. Neumann,

Nigel Whittle,

Nicolas Singewald

Publication year - 2015

Publication title -

the international journal of neuropsychopharmacology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.897

H-Index - 107

eISSN - 1469-5111

pISSN - 1461-1457

DOI - 10.1093/ijnp/pyv128

Subject(s) - extinction (optical mineralogy) , anxiety , psychology , anxiolytic , context (archaeology) , neuroscience , exposure therapy , fear conditioning , cycloserine , amygdala , medicine , psychiatry , chemistry , biology , paleontology , mineralogy , tuberculosis , pathology

Despite its success in treating specific anxiety disorders, the effect of exposure therapy is limited by problems with tolerability, treatment resistance, and fear relapse after initial response. The identification of novel drug targets facilitating fear extinction in clinically relevant animal models may guide improved treatment strategies for these disorders in terms of efficacy, acceleration of fear extinction, and return of fear.

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