Effects of the Synthetic Neurosteroid | Zendy

Lucie Parésys | Zendy; Kerstin Hoffmann | Zendy; Nicolas Froger | Zendy; Massimiliano Bianchi | Zendy; Isabelle Villey | Zendy; Étienne-Émile Baulieu | Zendy; Eberhard Fuchs | Zendy

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Effects of the Synthetic Neurosteroid

Author(s) -

Lucie Parésys,

Kerstin Hoffmann,

Nicolas Froger,

Massimiliano Bianchi,

Isabelle Villey,

Étienne-Émile Baulieu,

Eberhard Fuchs

Publication year - 2015

Publication title -

the international journal of neuropsychopharmacology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.897

H-Index - 107

eISSN - 1469-5111

pISSN - 1461-1457

DOI - 10.1093/ijnp/pyv119

Subject(s) - antidepressant , fluoxetine , pharmacology , reuptake inhibitor , serotonin , neuroactive steroid , medicine , psychology , endocrinology , receptor , hippocampus , gabaa receptor

Most currently available active antidepressant drugs are selective serotonin/noradrenaline reuptake inhibitors. However, as their clinical efficacy is not immediate, long-term administration is often accompanied by substantial side effects, and numerous patients remain non- or partial responders. We have recently found that the synthetic neurosteroid derivative 3β-methoxypregnenolone, which binds to the microtubule-associated protein-2, can provide a novel therapeutic approach in experimental model of depressive disorders in rats. To further validate the antidepressant-like efficacy of 3β-methoxypregnenolone, we investigated effects of a longer treatment (4-week oral administration; 50mg/kg/d) in a nonrodent species, the tree shrew, exposed to psychosocial stress that elicits close-to-human alterations observed in patients with depressive disorders.

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