Insulin-Like Growth Factor I Produces an Antidepressant-Like Effect and Elicits N-Methyl-D-Aspartate Receptor Independent Long-Term Potentiation of Synaptic Transmission in Medial Prefrontal Cortex and Hippocampus | Zendy

Jeffrey Burgdorf | Zendy; Xiao-lei Zhang | Zendy; Elizabeth M. Colechio | Zendy; Nayereh GhoreishiHaack | Zendy; Amanda L. Gross | Zendy; Roger A. Kroes | Zendy; Patric K. Stanton | Zendy; Joseph R. Moskal | Zendy

Open Access

Insulin-Like Growth Factor I Produces an Antidepressant-Like Effect and Elicits N-Methyl-D-Aspartate Receptor Independent Long-Term Potentiation of Synaptic Transmission in Medial Prefrontal Cortex and Hippocampus

Author(s) -

Jeffrey Burgdorf,

Xiao-lei Zhang,

Elizabeth M. Colechio,

Nayereh GhoreishiHaack,

Amanda L. Gross,

Roger A. Kroes,

Patric K. Stanton,

Joseph R. Moskal

Publication year - 2015

Publication title -

the international journal of neuropsychopharmacology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.897

H-Index - 107

eISSN - 1469-5111

pISSN - 1461-1457

DOI - 10.1093/ijnp/pyv101

Subject(s) - long term potentiation , neuroscience , prefrontal cortex , antidepressant , hippocampus , ampa receptor , long term depression , hippocampal formation , psychology , nmda receptor , medicine , receptor , cognition

Growth factors play an important role in regulating neurogenesis and synapse formation and may be involved in regulating the antidepressant response to conventional antidepressants. To date, Insulin-like growth factor I (IGFI) is the only growth factor that has shown antidepressant properties in human clinical trials. However, its mechanism of action remains unclear.

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