Local and Global Resting State Activity in the Noradrenergic and Dopaminergic Pathway Modulated by Reboxetine and Amisulpride in Healthy Subjects | Zendy

Coraline D. Metzger | Zendy; Maike Wiegers | Zendy; Martin Walter | Zendy; Birgit Abler | Zendy; Heiko Graf | Zendy

Open Access

Local and Global Resting State Activity in the Noradrenergic and Dopaminergic Pathway Modulated by Reboxetine and Amisulpride in Healthy Subjects

Author(s) -

Coraline D. Metzger,

Maike Wiegers,

Martin Walter,

Birgit Abler,

Heiko Graf

Publication year - 2015

Publication title -

the international journal of neuropsychopharmacology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.897

H-Index - 107

eISSN - 1469-5111

pISSN - 1461-1457

DOI - 10.1093/ijnp/pyv080

Subject(s) - amisulpride , locus coeruleus , dopaminergic , neuroscience , reboxetine , resting state fmri , pharmacology , psychology , medicine , dopamine , psychiatry , central nervous system , antidepressant , reuptake inhibitor , hippocampus , clozapine , schizophrenia (object oriented programming)

Various psychiatric populations are currently investigated with resting state fMRI, with the aim of individualizing diagnostics and treatment options and improving treatment outcomes. Many of these studies are conducted in large naturalistic samples, providing rich insights regarding disease-related neural alterations, but with the common psychopharmacological medication limiting interpretations of the results. We therefore investigated the effects of common noradrenergic and anti-dopaminergic medications on local and global resting state activity (rs-activity) in healthy volunteers to further the understanding of the respective effects independent from disease-related alterations.

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