Open AccessActivation of Protein Kinases and Phosphatases Coupled to Glutamate Receptors Regulates the Phosphorylation State of DARPP32 at Threonine 75 After Repeated Exposure to Cocaine in the Rat Dorsal Striatum in a Ca2+-Dependent Manner
Author(s) -
Jieun Kim,
In Soo Ryu,
Seungwan Seo,
Eun Sang Choe
Publication year - 2015
Publication title -
international journal of neuropsychopharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.897
H-Index - 107
eISSN - 1469-5111
pISSN - 1461-1457
DOI - 10.1093/ijnp/pyv075
Subject(s) - phosphorylation , kinase , phosphatase , glutamate receptor , protein kinase a , protein phosphorylation , protein kinase c , microbiology and biotechnology , synaptic plasticity , protein phosphatase 1 , chemistry , striatum , mitogen activated protein kinase , biology , biochemistry , dopamine , receptor , neuroscience
Phosphorylation state of dopamine- and cAMP-regulated phosphoprotein, molecular weight 32 kDa (DARPP32) is crucial to understand drug-mediated synaptic plasticity. In this study, mechanisms underlying repeated cocaine-stimulated phosphorylation of DARPP32 at threonine 75 (pDARPP32-Thr75) were determined by investigating the hypothesis that activation of protein kinases and phosphatases coupled to glutamate signaling is necessary for the regulation of pDARPP32-Thr75 after repeated cocaine administration.