Hippocampal-Dependent Antidepressant Action of the H3Receptor Antagonist Clobenpropit in a Rat Model of Depression | Zendy

Teresa Femenía | Zendy; Salvatore Magara | Zendy; Caitlin M. DuPont | Zendy; Maria Lindskog | Zendy

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Hippocampal-Dependent Antidepressant Action of the H₃Receptor Antagonist Clobenpropit in a Rat Model of Depression

Author(s) -

Teresa Femenía,

Salvatore Magara,

Caitlin M. DuPont,

Maria Lindskog

Publication year - 2015

Publication title -

the international journal of neuropsychopharmacology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.897

H-Index - 107

eISSN - 1469-5111

pISSN - 1461-1457

DOI - 10.1093/ijnp/pyv032

Subject(s) - depression (economics) , antidepressant , pharmacology , hippocampal formation , antagonist , medicine , psychology , neuroscience , hippocampus , receptor , economics , macroeconomics

Histamine is a modulatory neurotransmitter regulating neuronal activity. Antidepressant drugs target modulatory neurotransmitters, thus ultimately regulating glutamatergic transmission and plasticity. Histamine H3 receptor (H3R) antagonists have both pro-cognitive and antidepressant effects; however, the mechanism by which they modulate glutamate transmission is not clear. We measured the effects of the H3R antagonist clobenpropit in the Flinders Sensitive Line (FSL), a rat model of depression with impaired memory and altered glutamatergic transmission.

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