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Histamine is a modulatory neurotransmitter regulating neuronal activity. Antidepressant drugs target modulatory neurotransmitters, thus ultimately regulating glutamatergic transmission and plasticity. Histamine H3 receptor (H3R) antagonists have both pro-cognitive and antidepressant effects; however, the mechanism by which they modulate glutamate transmission is not clear. We measured the effects of the H3R antagonist clobenpropit in the Flinders Sensitive Line (FSL), a rat model of depression with impaired memory and altered glutamatergic transmission.

Hippocampal-Dependent Antidepressant Action of the H3Receptor Antagonist Clobenpropit in a Rat Model of Depression

Hippocampal-Dependent Antidepressant Action of the H₃Receptor Antagonist Clobenpropit in a Rat Model of Depression