The Class I-Specific HDAC Inhibitor MS-275 Decreases Motivation to Consume Alcohol and Relapse in Heavy Drinking Rats | Zendy

Jérôme Jeanblanc | Zendy; Sandrine Lemoine | Zendy; Virginie Jeanblanc | Zendy; Stéphanie AlauxCantin | Zendy; Mickaël Naassïla | Zendy

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The Class I-Specific HDAC Inhibitor MS-275 Decreases Motivation to Consume Alcohol and Relapse in Heavy Drinking Rats

Author(s) -

Jérôme Jeanblanc,

Sandrine Lemoine,

Virginie Jeanblanc,

Stéphanie AlauxCantin,

Mickaël Naassïla

Publication year - 2015

Publication title -

the international journal of neuropsychopharmacology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.897

H-Index - 107

eISSN - 1469-5111

pISSN - 1461-1457

DOI - 10.1093/ijnp/pyv029

Subject(s) - nucleus accumbens , self administration , ethanol , striatum , histone , histone deacetylase , epigenetics , alcohol dependence , addiction , pharmacology , medicine , endocrinology , alcohol , chemistry , psychology , neuroscience , dopamine , biochemistry , gene

New strategies for the treatment of alcohol dependence are a pressing need, and recent evidence suggests that targeting enzymes involved in epigenetic mechanisms seems to have great potential. Among these mechanisms, alteration of histone acetylation by histone deacetylases is of great importance for gene expression and has also been implicated in addiction. Here, we examined whether intra-cerebroventricular administration of MS-275, a class I-specific histone deacetylase inhibitor, could alter ethanol self-administration, motivation to consume ethanol, and relapse in heavy drinking rats.

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