Differences in Anxiety-Like Behavior within a Batch of Wistar Rats Are Associated with Differences in Serotonergic Transmission, Enhanced by Acute SRI Administration, and Abolished By Serotonin Depletion | Zendy

Jakob Näslund | Zendy; Erik Studer | Zendy; Robert Pettersson | Zendy; Melker Hagsäter | Zendy; Staffan Nilsson | Zendy; Hans Nissbrandt | Zendy; Elias Eriksson | Zendy

Open Access

Differences in Anxiety-Like Behavior within a Batch of Wistar Rats Are Associated with Differences in Serotonergic Transmission, Enhanced by Acute SRI Administration, and Abolished By Serotonin Depletion

Author(s) -

Jakob Näslund,

Erik Studer,

Robert Pettersson,

Melker Hagsäter,

Staffan Nilsson,

Hans Nissbrandt,

Elias Eriksson

Publication year - 2015

Publication title -

the international journal of neuropsychopharmacology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.897

H-Index - 107

eISSN - 1469-5111

pISSN - 1461-1457

DOI - 10.1093/ijnp/pyv018

Subject(s) - serotonergic , serotonin , tryptophan hydroxylase , anxiogenic , serotonin reuptake inhibitor , psychology , paroxetine , reuptake inhibitor , serotonin uptake inhibitors , medicine , endocrinology , anxiety , pharmacology , psychiatry , fluoxetine , anxiolytic , receptor

The anxiety-reducing effect of long-term administration of serotonin reuptake inhibitors is usually seen only in subjects with anxiety disorders, and such patients are also abnormally inclined to experience a paradoxical anxiety-enhancing effect of acute serotonin reuptake inhibition. These unique responses to serotonin reuptake inhibitors in anxiety-prone subjects suggest, as do genetic association studies, that inter-individual differences in anxiety may be associated with differences in serotonergic transmission.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research