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Tetramethylpyrazine Produces Antidepressant-Like Effects in Mice Through Promotion of BDNF Signaling Pathway
Author(s) -
Bo Jiang,
Chao Huang,
Xiangfan Chen,
Lijuan Tong,
Wei Zhang
Publication year - 2015
Publication title -
the international journal of neuropsychopharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.897
H-Index - 107
eISSN - 1469-5111
pISSN - 1461-1457
DOI - 10.1093/ijnp/pyv010
Subject(s) - tetramethylpyrazine , antidepressant , neuroprotection , pharmacology , depression (economics) , medicine , resveratrol , hippocampus , alternative medicine , pathology , economics , macroeconomics
Current antidepressants are clinically effective only after several weeks of administration. Tetramethylpyrazine (TMP) is an identified component of Ligusticum wallichii with neuroprotective effects. Here, we investigated the antidepressant effects of TMP in mice models of depression.

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