PI3K/AKT/mTOR Signaling-Mediated Neuropeptide VGF in the Hippocampus of Mice Is Involved in the Rapid Onset Antidepressant-Like Effects of GLYX-13 | Zendy

Lu Yang | Zendy; Chuang Wang | Zendy; Zhancheng Xue | Zendy; Chenli Li | Zendy; Junfang Zhang | Zendy; Xin Zhao | Zendy; Aiming Liu | Zendy; Qinwen Wang | Zendy; Wenhua Zhou | Zendy

Open Access

PI3K/AKT/mTOR Signaling-Mediated Neuropeptide VGF in the Hippocampus of Mice Is Involved in the Rapid Onset Antidepressant-Like Effects of GLYX-13

Author(s) -

Lu Yang,

Chuang Wang,

Zhancheng Xue,

Chenli Li,

Junfang Zhang,

Xin Zhao,

Aiming Liu,

Qinwen Wang,

Wenhua Zhou

Publication year - 2015

Publication title -

the international journal of neuropsychopharmacology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.897

H-Index - 107

eISSN - 1469-5111

pISSN - 1461-1457

DOI - 10.1093/ijnp/pyu110

Subject(s) - pi3k/akt/mtor pathway , protein kinase b , behavioural despair test , ly294002 , hippocampus , phosphatidylinositol , neuroprotection , kinase , antidepressant , endocrinology , pharmacology , signal transduction , medicine , biology , microbiology and biotechnology

VGF (nonacryonimic) and phosphatidylinositol 3-kinase (PI3K)/AKT (also known as protein kinase B, PKB)/mammalian target of rapamycin (mTOR) signaling play pivotal roles in depression. However, whether phosphatidylinositol 3-kinase/AKT/mTOR signaling-mediated VGF participates in rapid-acting antidepressant-like actions of GLYX-13 is unclear.

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