Cannabinoid Modulation of Amygdala Subregion Functional Connectivity to Social Signals of Threat | Zendy

Stephanie M. Gorka | Zendy; Daniel A. Fitzgerald | Zendy; Harriet de Wit | Zendy; K. Luan Phan | Zendy

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Cannabinoid Modulation of Amygdala Subregion Functional Connectivity to Social Signals of Threat

Author(s) -

Stephanie M. Gorka,

Daniel A. Fitzgerald,

Harriet de Wit,

K. Luan Phan

Publication year - 2014

Publication title -

the international journal of neuropsychopharmacology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.897

H-Index - 107

eISSN - 1469-5111

pISSN - 1461-1457

DOI - 10.1093/ijnp/pyu104

Subject(s) - amygdala , prefrontal cortex , basolateral amygdala , neuroscience , psychology , functional magnetic resonance imaging , ventromedial prefrontal cortex , anterior cingulate cortex , extinction (optical mineralogy) , tetrahydrocannabinol , cannabinoid , cognition , medicine , chemistry , mineralogy , receptor

Δ(9)-Tetrahydrocannabinol has been shown to modulate anxiety and facilitate the extinction of fear by inhibiting amygdala reactivity. Since functional coupling between the amygdala and prefrontal cortex is implicated in affective processes, it is possible that Δ(9)-tetrahydrocannabinol affects amygdala-prefrontal cortex functional connectivity in ways that differ across amygdala subregions: basolateral, centromedial, and superficial.

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