Melancholic-Like Behaviors and Circadian Neurobiological Abnormalities in Melatonin MT1 Receptor Knockout Mice | Zendy

Stefano Comai | Zendy; Rafael OchoaSanchez | Zendy; Sergio Domínguez-López | Zendy; Francis Rodriguez Bambico | Zendy; Gabriella Gobbi | Zendy

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Melancholic-Like Behaviors and Circadian Neurobiological Abnormalities in Melatonin MT1 Receptor Knockout Mice

Author(s) -

Stefano Comai,

Rafael OchoaSanchez,

Sergio Domínguez-López,

Francis Rodriguez Bambico,

Gabriella Gobbi

Publication year - 2015

Publication title -

the international journal of neuropsychopharmacology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.897

H-Index - 107

eISSN - 1469-5111

pISSN - 1461-1457

DOI - 10.1093/ijnp/pyu075

Subject(s) - circadian rhythm , endocrinology , medicine , corticosterone , psychology , melatonin , serotonergic , knockout mouse , locus coeruleus , neuroscience , serotonin , biology , receptor , central nervous system , hormone

Melancholic depression, described also as endogenous depression, is a mood disorder with distinctive specific psychopathological features and biological homogeneity, including anhedonia, circadian variation of mood, psychomotor activation, weight loss, diurnal cortisol changes, and sleep disturbances. Although several hypotheses have been proposed, the etiology of this disorder is still unknown.

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