Astrocytic NMDA Receptors in the Basolateral Amygdala Contribute to Facilitation of Fear Extinction | Zendy

Gajanan P. Shelkar | Zendy; Jinxu Liu | Zendy; Shashank M. Dravid | Zendy

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Astrocytic NMDA Receptors in the Basolateral Amygdala Contribute to Facilitation of Fear Extinction

Author(s) -

Gajanan P. Shelkar,

Jinxu Liu,

Shashank M. Dravid

Publication year - 2021

Publication title -

the international journal of neuropsychopharmacology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.897

H-Index - 107

eISSN - 1469-5111

pISSN - 1461-1457

DOI - 10.1093/ijnp/pyab055

Subject(s) - basolateral amygdala , ampa receptor , nmda receptor , neuroscience , extinction (optical mineralogy) , amygdala , fear processing in the brain , glutamate receptor , psychology , receptor , chemistry , fear conditioning , medicine , endocrinology , biology , mineralogy

Enhancement of N-methyl-D-aspartate (NMDA) receptor function using glycine-site agonist D-cycloserine is known to facilitate fear extinction, providing a means to augment cognitive behavioral therapy in anxiety disorders. A novel class of glycine-site agonists has recently been identified, and we have found that the prototype, AICP, is more effective than D-cycloserine in modulating neuronal function.

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