Orchestration of Dopamine Neuron Population Activity in the Ventral Tegmental Area by Caffeine: Comparison With Amphetamine | Zendy

Ornella Valenti | Zendy; Alice Zambon | Zendy; Stefan Boehm | Zendy

Open Access

Orchestration of Dopamine Neuron Population Activity in the Ventral Tegmental Area by Caffeine: Comparison With Amphetamine

Author(s) -

Ornella Valenti,

Alice Zambon,

Stefan Boehm

Publication year - 2021

Publication title -

the international journal of neuropsychopharmacology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.897

H-Index - 107

eISSN - 1469-5111

pISSN - 1461-1457

DOI - 10.1093/ijnp/pyab049

Subject(s) - ventral tegmental area , amphetamine , dopamine , population , pharmacology , caffeine , conditioned place preference , dopamine transporter , neuroscience , medicine , psychology , dopaminergic , environmental health

Among psychostimulants, the dopamine transporter ligands amphetamine and cocaine display the highest addictive potential; the adenosine receptor antagonist caffeine is most widely consumed but less addictive. Psychostimulant actions of amphetamine were correlated with its ability to orchestrate ventral tegmental dopamine neuron activity with contrasting shifts in firing after single vs repeated administration. Whether caffeine might impinge on dopamine neuron activity has remained elusive.

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