Genome-Wide Correlation of DNA Methylation and Gene Expression in Postmortem Brain Tissues of Opioid Use Disorder Patients | Zendy

Andi Liu | Zendy; Yulin Dai | Zendy; Emily Méndez | Zendy; Ruifeng Hu | Zendy; Gabriel R. Fries | Zendy; Katherine Najera | Zendy; Shan Jiang | Zendy; Thomas D. Meyer | Zendy; Laura Stertz | Zendy; Peilin Jia | Zendy; Consuelo WalssBass | Zendy; Zhongming Zhao | Zendy

Open Access

Genome-Wide Correlation of DNA Methylation and Gene Expression in Postmortem Brain Tissues of Opioid Use Disorder Patients

Author(s) -

Andi Liu,

Yulin Dai,

Emily Méndez,

Ruifeng Hu,

Gabriel R. Fries,

Katherine Najera,

Shan Jiang,

Thomas D. Meyer,

Laura Stertz,

Peilin Jia,

Consuelo WalssBass,

Zhongming Zhao

Publication year - 2021

Publication title -

the international journal of neuropsychopharmacology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.897

H-Index - 107

eISSN - 1469-5111

pISSN - 1461-1457

DOI - 10.1093/ijnp/pyab043

Subject(s) - dna methylation , transcriptome , biology , epigenetics , genetics , gene , methylation , gene expression profiling , gene expression , regulation of gene expression

Opioid use disorder (OUD) affects millions of people, causing nearly 50 000 deaths annually in the United States. While opioid exposure and OUD are known to cause widespread transcriptomic and epigenetic changes, few studies in human samples have been conducted. Understanding how OUD affects the brain at the molecular level could help decipher disease pathogenesis and shed light on OUD treatment.

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