Open AccessDysregulation of Protein Kinase C in Adult Depression and Suicide: Evidence From Postmortem Brain Studies
Author(s) -
Ghanshyam N. Pandey,
Anuradha Sharma,
Hooriyah S. Rizavi,
Xinguo Ren
Publication year - 2021
Publication title -
international journal of neuropsychopharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.897
H-Index - 107
eISSN - 1469-5111
pISSN - 1461-1457
DOI - 10.1093/ijnp/pyab003
Subject(s) - protein kinase c , prefrontal cortex , isozyme , postmortem studies , serotonin , medicine , psychology , cytosol , endocrinology , biology , neuroscience , kinase , microbiology and biotechnology , enzyme , receptor , biochemistry , cognition
Several lines of evidence suggest the abnormalities of protein kinase C (PKC) signaling system in mood disorders and suicide based primarily on the studies of PKC and its isozymes in the platelets and postmortem brain of depressed and suicidal subjects. In this study, we examined the role of PKC isozymes in depression and suicide.