Open AccessAppraising the causal relevance of DNA methylation for risk of lung cancer
Author(s) -
Thomas Battram,
Rebecca C. Richmond,
Laura Baglietto,
Philip Haycock,
Vittorio Perduca,
Stig E. Bojesen,
Tom R. Gaunt,
Gibran Hemani,
Florence Guida,
Robert CarrerasTorres,
Rayjean J. Hung,
Christopher I. Amos,
Joshua R. Freeman,
Torkjel M. Sandanger,
Therese Haugdahl Nøst,
Børge G. Nordestgaard,
Andrew E. Teschendorff,
Silvia Polidoro,
Paolo Vineis,
Gianluca Severi,
Allison Hodge,
Graham G. Giles,
Kjell Grankvist,
Mikael B Johansson,
Mattias Johansson,
George Davey Smith,
Caroline L. Relton
Publication year - 2019
Publication title -
international journal of epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.406
H-Index - 208
eISSN - 1464-3685
pISSN - 0300-5771
DOI - 10.1093/ije/dyz190
Subject(s) - lung cancer , dna methylation , relevance (law) , methylation , medicine , oncology , bioinformatics , biology , computational biology , dna , genetics , gene , gene expression , political science , law
DNA methylation changes in peripheral blood have recently been identified in relation to lung cancer risk. Some of these changes have been suggested to mediate part of the effect of smoking on lung cancer. However, limitations with conventional mediation analyses mean that the causal nature of these methylation changes has yet to be fully elucidated.
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