The genetic interplay between body mass index, breast size and breast cancer risk: a Mendelian randomization analysis | Zendy

Brandon Nick Sern Ooi | Zendy; Huiwen Loh | Zendy; Peh Joo Ho | Zendy; Roger L. Milne | Zendy; Graham G. Giles | Zendy; Chi Gao | Zendy; Peter Kraft | Zendy; Esther M. John | Zendy; Anthony J. Swerdlow | Zendy; Hermann Brenner | Zendy; Anna H. Wu | Zendy; Christopher A. Haiman | Zendy; D. Gareth Evans | Zendy; Wei Zheng | Zendy; Peter A. Fasching | Zendy; Jose E. Castelao | Zendy; Ava Kwong | Zendy; Xia Shen | Zendy; Kamila Czene | Zendy; Per Hall | Zendy; Alison M. Dunning | Zendy; Douglas F. Easton | Zendy; Mikael Hartman | Zendy; Jingmei Li | Zendy

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The genetic interplay between body mass index, breast size and breast cancer risk: a Mendelian randomization analysis

Author(s) -

Brandon Nick Sern Ooi,

Huiwen Loh,

Peh Joo Ho,

Roger L. Milne,

Graham G. Giles,

Chi Gao,

Peter Kraft,

Esther M. John,

Anthony J. Swerdlow,

Hermann Brenner,

Anna H. Wu,

Christopher A. Haiman,

D. Gareth Evans,

Wei Zheng,

Peter A. Fasching,

Jose E. Castelao,

Ava Kwong,

Xia Shen,

Kamila Czene,

Per Hall,

Alison M. Dunning,

Douglas F. Easton,

Mikael Hartman,

Jingmei Li

Publication year - 2019

Publication title -

international journal of epidemiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.406

H-Index - 208

eISSN - 1464-3685

pISSN - 0300-5771

DOI - 10.1093/ije/dyz124

Subject(s) - mendelian randomization , breast cancer , body mass index , medicine , oncology , mendelian inheritance , randomization , cancer , genetics , clinical trial , biology , genotype , genetic variants , gene

Evidence linking breast size to breast cancer risk has been inconsistent, and its interpretation is often hampered by confounding factors such as body mass index (BMI). Here, we used linkage disequilibrium score regression and two-sample Mendelian randomization (MR) to examine the genetic associations between BMI, breast size and breast cancer risk.

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