Exploring the role of genetic confounding in the association between maternal and offspring body mass index: evidence from three birth cohorts | Zendy

Tom A. Bond | Zendy; Ville Karhunen | Zendy; Matthias Wielscher | Zendy; Juha Auvinen | Zendy; Minna Männikkö | Zendy; Sirkka KeinänenKiukaanniemi | Zendy; Marc J. Gunter | Zendy; Janine F. Felix | Zendy; Inga Prokopenko | Zendy; Jian Yang | Zendy; Peter M. Visscher | Zendy; David M. Evans | Zendy; Sylvain Sebért | Zendy; Alex Lewin | Zendy; Paul F. O’Reilly | Zendy; Debbie A. Lawlor | Zendy; MarjoRiitta Järvelin | Zendy

Open Access

Exploring the role of genetic confounding in the association between maternal and offspring body mass index: evidence from three birth cohorts

Author(s) -

Tom A. Bond,

Ville Karhunen,

Matthias Wielscher,

Juha Auvinen,

Minna Männikkö,

Sirkka KeinänenKiukaanniemi,

Marc J. Gunter,

Janine F. Felix,

Inga Prokopenko,

Jian Yang,

Peter M. Visscher,

David M. Evans,

Sylvain Sebért,

Alex Lewin,

Paul F. O’Reilly,

Debbie A. Lawlor,

MarjoRiitta Järvelin

Publication year - 2019

Publication title -

international journal of epidemiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.406

H-Index - 208

eISSN - 1464-3685

pISSN - 0300-5771

DOI - 10.1093/ije/dyz095

Subject(s) - offspring , confounding , body mass index , pregnancy , demography , birth weight , confidence interval , single nucleotide polymorphism , medicine , biology , genotype , genetics , sociology , gene

Maternal pre-pregnancy body mass index (BMI) is positively associated with offspring birth weight (BW) and BMI in childhood and adulthood. Each of these associations could be due to causal intrauterine effects, or confounding (genetic or environmental), or some combination of these. Here we estimate the extent to which the association between maternal BMI and offspring body size is explained by offspring genotype, as a first step towards establishing the importance of genetic confounding.

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