Circulating vitamin D concentrations and risk of breast and prostate cancer: a Mendelian randomization study | Zendy

Xia Jiang | Zendy; Niki Dimou | Zendy; Kawthar Al-Dabhani | Zendy; Sarah J. Lewis | Zendy; Richard M. Martin | Zendy; Philip Haycock | Zendy; Marc J. Gunter | Zendy; Timothy J. Key | Zendy; Rosalind A. Eeles | Zendy; Kenneth Muir | Zendy; David E. Neal | Zendy; Graham G. Giles | Zendy; Edward L. Giovannucci | Zendy; Meir J. Stampfer | Zendy; Brandon L. Pierce | Zendy; Joellen M. Schildkraut | Zendy; Shaneda Warren Andersen | Zendy; Deborah J. Thompson | Zendy; Wei Zheng | Zendy; Peter Kraft | Zendy; Konstantinos K. Tsilidis | Zendy

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Circulating vitamin D concentrations and risk of breast and prostate cancer: a Mendelian randomization study

Author(s) -

Xia Jiang,

Niki Dimou,

Kawthar Al-Dabhani,

Sarah J. Lewis,

Richard M. Martin,

Philip Haycock,

Marc J. Gunter,

Timothy J. Key,

Rosalind A. Eeles,

Kenneth Muir,

David E. Neal,

Graham G. Giles,

Edward L. Giovannucci,

Meir J. Stampfer,

Brandon L. Pierce,

Joellen M. Schildkraut,

Shaneda Warren Andersen,

Deborah J. Thompson,

Wei Zheng,

Peter Kraft,

Konstantinos K. Tsilidis

Publication year - 2018

Publication title -

international journal of epidemiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.406

H-Index - 208

eISSN - 1464-3685

pISSN - 0300-5771

DOI - 10.1093/ije/dyy284

Subject(s) - mendelian randomization , medicine , prostate cancer , breast cancer , oncology , prostate , randomization , gynecology , cancer , clinical trial , biology , gene , genetics , genetic variants , genotype

Observational studies have suggested an association between circulating vitamin D concentrations [25(OH)D] and risk of breast and prostate cancer, which was not supported by a recent Mendelian randomization (MR) analysis comprising 15 748 breast and 22 898 prostate-cancer cases. Demonstrating causality has proven challenging and one common limitation of MR studies is insufficient power.

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