Using genetics to understand the causal influence of higher BMI on depression | Zendy

Jessica Tyrrell | Zendy; Anwar Mulugeta | Zendy; Andrew R. Wood | Zendy; Ang Zhou | Zendy; Robin N. Beaumont | Zendy; Marcus A. Tuke | Zendy; Samuel E. Jones | Zendy; Katherine S. Ruth | Zendy; Hanieh Yaghootkar | Zendy; Seth A. Sharp | Zendy; William Thompson | Zendy; Yingjie Ji | Zendy; James Harrison | Zendy; Rachel M. Freathy | Zendy; Anna Murray | Zendy; Michael N. Weedon | Zendy; Cathryn M. Lewis | Zendy; Timothy M. Frayling | Zendy; Elina Hyppönen | Zendy

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Using genetics to understand the causal influence of higher BMI on depression

Author(s) -

Jessica Tyrrell,

Anwar Mulugeta,

Andrew R. Wood,

Ang Zhou,

Robin N. Beaumont,

Marcus A. Tuke,

Samuel E. Jones,

Katherine S. Ruth,

Hanieh Yaghootkar,

Seth A. Sharp,

William Thompson,

Yingjie Ji,

James Harrison,

Rachel M. Freathy,

Anna Murray,

Michael N. Weedon,

Cathryn M. Lewis,

Timothy M. Frayling,

Elina Hyppönen

Publication year - 2018

Publication title -

international journal of epidemiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.406

H-Index - 208

eISSN - 1464-3685

pISSN - 0300-5771

DOI - 10.1093/ije/dyy223

Subject(s) - mendelian randomization , odds ratio , depression (economics) , body mass index , obesity , medicine , confidence interval , odds , demography , logistic regression , genetics , genotype , biology , genetic variants , sociology , macroeconomics , economics , gene

Depression is more common in obese than non-obese individuals, especially in women, but the causal relationship between obesity and depression is complex and uncertain. Previous studies have used genetic variants associated with BMI to provide evidence that higher body mass index (BMI) causes depression, but have not tested whether this relationship is driven by the metabolic consequences of BMI nor for differences between men and women.

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