Relationship of genetic determinants of height with cardiometabolic and pulmonary traits in the Hispanic Community Health Study/Study of Latinos | Zendy

Tamar Sofer | Zendy; JeeYoung Moon | Zendy; Carmen R. Isasi | Zendy; Qibin Qi | Zendy; Neomi Shah | Zendy; Robert C. Kaplan | Zendy; Mark H. Kuniholm | Zendy

Open Access

Relationship of genetic determinants of height with cardiometabolic and pulmonary traits in the Hispanic Community Health Study/Study of Latinos

Author(s) -

Tamar Sofer,

JeeYoung Moon,

Carmen R. Isasi,

Qibin Qi,

Neomi Shah,

Robert C. Kaplan,

Mark H. Kuniholm

Publication year - 2018

Publication title -

international journal of epidemiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.406

H-Index - 208

eISSN - 1464-3685

pISSN - 0300-5771

DOI - 10.1093/ije/dyy177

Subject(s) - mendelian randomization , demography , medicine , genome wide association study , vital capacity , single nucleotide polymorphism , biology , genotype , genetics , lung function , genetic variants , lung , sociology , gene , diffusing capacity

Associations of adult height with cardiometabolic and pulmonary traits have been studied in majority European ancestry populations using Mendelian randomization and polygenic risk score (PRS) analysis. The standard PRS approach entails creating a PRS for height using variants identified in prior genome-wide association studies (GWAS). It is unclear how well the standard PRS approach performs in non-European populations and whether height-trait associations observed in Europeans are also observed in other populations.

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