Epigenome-wide association study in whole blood on type 2 diabetes among sub-Saharan African individuals: findings from the RODAM study | Zendy

Karlijn Meeks | Zendy; Peter Henneman | Zendy; Andrea Venema | Zendy; Juliet Addo | Zendy; Silver Bahendeka | Zendy; Tom Burr | Zendy; Ina Danquah | Zendy; Cecilia Galbete | Zendy; Marcel M.A.M. Mannens | Zendy; Frank P. Mockenhaupt | Zendy; Ellis OwusuDabo | Zendy; Charles N. Rotimi | Zendy; Matthias B. Schulze | Zendy; Liam Smeeth | Zendy; Joachim Spranger | Zendy; Mohammad Hadi Zafarmand | Zendy; Adebowale Adeyemo | Zendy; Charles Agyemang | Zendy

Open Access

Epigenome-wide association study in whole blood on type 2 diabetes among sub-Saharan African individuals: findings from the RODAM study

Author(s) -

Karlijn Meeks,

Peter Henneman,

Andrea Venema,

Juliet Addo,

Silver Bahendeka,

Tom Burr,

Ina Danquah,

Cecilia Galbete,

Marcel M.A.M. Mannens,

Frank P. Mockenhaupt,

Ellis OwusuDabo,

Charles N. Rotimi,

Matthias B. Schulze,

Liam Smeeth,

Joachim Spranger,

Mohammad Hadi Zafarmand,

Adebowale Adeyemo,

Charles Agyemang

Publication year - 2018

Publication title -

international journal of epidemiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.406

H-Index - 208

eISSN - 1464-3685

pISSN - 0300-5771

DOI - 10.1093/ije/dyy171

Subject(s) - type 2 diabetes , dna methylation , epigenome , epigenetics , biology , genetics , body mass index , genome wide association study , bioinformatics , diabetes mellitus , gene , single nucleotide polymorphism , genotype , endocrinology , gene expression

Type 2 diabetes (T2D) results from a complex interplay between genetics and the environment. Several epigenome-wide association studies (EWAS) have found DNA methylation loci associated with T2D in European populations. However, data from African populations are lacking. We undertook the first EWAS for T2D among sub-Saharan Africans, aiming at identifying ubiquitous and novel DNA methylation loci associated with T2D.

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